英语翻译Transcription-coupled DNA repair uses components of the transcription machinery to identify DNA lesions and initiate their repair.These repair pathways are complex,so their mechanistic features remain poorly understood.Bacterial transcrip

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英语翻译Transcription-coupled DNA repair uses components of the transcription machinery to identify DNA lesions and initiate their repair.These repair pathways are complex,so their mechanistic features remain poorly understood.Bacterial transcrip

英语翻译Transcription-coupled DNA repair uses components of the transcription machinery to identify DNA lesions and initiate their repair.These repair pathways are complex,so their mechanistic features remain poorly understood.Bacterial transcrip
英语翻译
Transcription-coupled DNA repair uses components of the transcription machinery to identify DNA lesions and initiate their repair.These repair pathways are complex,so their mechanistic features remain poorly understood.Bacterial transcription-coupled repair is initiated when RNA polymerase stalled at a DNA lesion is removed by Mfd,an ATP-dependent DNA translocase1,2,3.Here we use single-molecule DNA nanomanipulation to observe the dynamic interactions of Escherichia coli Mfd with RNA polymerase elongation complexes stalled by a cyclopyrimidine dimer or by nucleotide starvation.We show that Mfd acts by catalysing two irreversible,ATP-dependent transitions with different structural,kinetic and mechanistic features.Mfd remains bound to the DNA in a long-lived complex that could act as a marker for sites of DNA damage,directing assembly of subsequent DNA repair factors.These results provide a framework for considering the kinetics of transcription-coupled repair in vivo,and open the way to reconstruction of complete DNA repair pathways at single-molecule resolution.

英语翻译Transcription-coupled DNA repair uses components of the transcription machinery to identify DNA lesions and initiate their repair.These repair pathways are complex,so their mechanistic features remain poorly understood.Bacterial transcrip
DNA转录偶联修复使用的转录机器识别DNA损伤,并启动其维修的组件.这些修复途径很复杂,所以机械功能仍知之甚少.RNA聚合酶的DNA病变停滞在启动时的ATP-依赖的DNA反禄ASE1,2,3的MFD,除去细菌转录偶联修复.在这里,我们使用单分子DNA纳米操纵,动态观察MFD停滞的cyclopyrimi用餐二聚体或核苷酸饥饿与RNA聚合酶伸长复合物相互作用的大肠杆菌.我们发现,通过促进两个不可逆的,依赖于ATP的转换具有不同的结构,动力学和机械功能的MFD行为. K.K.制的保持在一个长寿命的复杂程度,作为DNA损伤位点的标记物,指示组件的随后的DNA修复因子的DNA结合.这些结果提供了一个框架,考虑在体内的转录偶联修复的动力学,单分子分辨率重建完整的DNA修复途径,在打开的方式

transcription是什么意思 pervasive transcription transcription start reverse transcription reverse transcription 英语翻译还有差别基因转录（differential gene transcription）的名词解释，3QQ~ 英语翻译$(co) 英语翻译$(co) 英语翻译$(co) 英语翻译co transcription factors是什么意思 text transcription 甚么意思 bam transcription什么意思? 英语翻译Hyperphosphorylation of pRb releases the transcription factor E2F stimulating entry into the DNA synthesis phase of the cell cycle. 英语翻译Music transcription could be defined as an act oflistening to a piece of music and writing down musicnotation for the piece.Transcription of polyphonicmusic (polyphonic pitch recognition) converts anacoustical waveform into a parametric r 英语翻译Transcription-coupled DNA repair uses components of the transcription machinery to identify DNA lesions and initiate their repair.These repair pathways are complex,so their mechanistic features remain poorly understood.Bacterial transcrip 请问transcription protocol怎么翻译 英语翻译co.,ltd.